Refining eligibility criteria for amyotrophic lateral sclerosis clinical trials
نویسندگان
چکیده
منابع مشابه
Outcome measures in amyotrophic lateral sclerosis clinical trials.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with an average survival of 3-5 years. While therapies for ALS remain limited, basic and translational ALS research has been host to numerous influential discoveries in recent years. These discoveries have led to a large pipeline of potential therapies that await testing in clinical trials. Until recently, ALS clinical trials ha...
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(1) Department of Clinical Neurological Sciences, The University of Western Ontario, London, Ontario, Canada (2) Psychological Services, London Health Sciences Centre, London, Ontario, Canada (3) Division of Neurology, Behavioural Neurology Program, and Rotman Research Institute, Baycrest; Division of Neurology, Department of Medicine, Mt. Sinai Hospital, University Health Network, and Universi...
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Amyotrophic Lateral Sclerosis (ALS) is unique among the neuromuscular diseases (NMD) in that it’s diagnosis is clinical, and cannot be made with genetic tests, biopsies, or imaging. Current ALS diagnostic criteria reflect what “the experts” believe ALS is, not necessarily what ALS really is. Consequently, some 10 to 20% of ALS patients do not meet current diagnostic criteria. Bayesian diagnosis...
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OBJECTIVES The use of clinical staging in the fatal neurodegenerative disease amyotrophic lateral sclerosis would have value in optimising future therapeutic trials. We aimed to use previous clinical trial data to determine the length of time patients spend in each of four proposed stages, its range and transition patterns to subsequent stages. METHODS Using databases from two multicentre cli...
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ژورنال
عنوان ژورنال: Neurology
سال: 2019
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.0000000000006855